The chemotherapy is a treatment that causes various side effects in patients who undergo there, among the most common are: nausea, weakness, various types of pain and inflammatory processes.
Research in this field has allowed us to understand that the side effects of chemotherapy are related to senescent cells. Cells stop dividing because it reached the end of their life and that release a cocktail of chemicals harmful to the surrounding tissues.
A group of researchers has developed a drug that can selectively attack the senescent cells in mice and reduce the side effects, helping to make the most effective treatment.
Let’s see how the researchers have come to this important result …
How to limit the side effects of chemotherapy?
In the body of the first group of mice, researchers have facilitated the development of senescent cells and subsequently inoculated cancer, which then was treated with the most common chemotherapy treatments.
The researchers were able to observe how after the start of chemotherapy these mice have shown the first side effects due to treatment (heart problems and bone marrow).
In a second group of mice, one week after treatment, researchers have instead given a drug able to eliminate senescent cells. As a result, in this group of mice, they have been no side effects presented by the first group, and also the number of relapses was lower compared to the case study.
Scientific research in the field of senescent cells and their relationship with the chemotherapy treatment is very prolific, some researchers have in fact conducted other experiments on the blood cells of women with breast cancer. From this research, it was found that patients who, before starting chemotherapy, had a greater number of senescent cells, have also accused more invasive side effects during treatment.
Being able to eliminate senescent cells could, according to this preliminary study, helping to limit the damage.
It must be said that today there is no drug that can act on human beings, in the way it works in mice. The experiment, if conducted on humans, would cause a shortage of platelets in the blood. Research in this area is evolving rapidly and, soon, a new drug is tested on a group of patients, able to fight senescent cells in articular cartilage.
The side effects of chemotherapy
The chemotherapy is different types of cancer effectively. But, as every treatment has side effects, which depend on several factors …
- Type of cancer
- Drugs and doses
- General health status
Because chemotherapy causes side effects?
The chemotherapy acts on the active cells in the body. The cancer cells are active cells, as well as healthy ones. These include cells in the blood, into the mouth, the digestive system and hair follicles.
Side effects occur when chemotherapy damages healthy cells.
You may also like to read another article on BestAntiBiotic: Stop to cardiac arrhythmias: Tested a map that identifies and blocks
Common side effects
Below, we offer a list of the most common side effects of chemotherapy …
- Fatigue: It is a persistent feeling of physical exhaustion, emotional and mental. Undergo different treatments, such as chemotherapy and radiation therapy; it may increase the sense of fatigue.
- Pain and inflammation of the mouth and throat: Chemotherapy can damage the cells of the mouth and throat, causing painful inflammation, such as mucositis. Which generally occurs between 5 and 14 days after treatment and vanishes completed treatment.
- Gastrointestinal disorders: Diarrhea, nausea and vomiting, loss of appetite.
- Disorders of the blood: The marrow is a spongy tissue found inside bones, and produces new blood cells. Chemotherapy going to hit this very process.
- Effects on the nervous system: Some drugs used in chemotherapy cause nerve damage, whose symptoms include tingling, inflammation, weakness or numbness in the hands or feet or both, fatigue or soreness of the muscles, loss of balance, tremors, vision problems, hearing.
- Sexual and reproductive problems: Chemotherapy can affect the reproductive capacity of the individual who is undergoing the treatment.
- Hair loss: Some types of chemotherapy cause hair loss, this can occur gradually or strands. Usually it begins after a few weeks from the start of chemotherapy and undergoes an increase.
- Recall radiation: It is a rash that looks like a severe sunburn. Although rare, it occurs when certain types of chemotherapy are made during or immediately after a chemotherapy treatment outside.
Side effects of long-term chemotherapy
Almost all the side effects disappear after treatment. Some types of chemotherapy can lead to permanent damage to the heart, lung, liver, kidney or reproductive system. Cognitive impairment can last for months or years after treatment.
Children undergoing chemotherapy may instead show side effects after several months or even years after the end of treatment. Among the long-term effects should be included an increase of the risk factor of recurrence and of contracting another cancer.Tags: Chemotherapy